The Empowering Neurologist Podcast

The ALS Case Challenging What Neurology Thought Was Impossible with Dr. M. Marc Abreu | E225

September 15, 2026·56 min
Episode Description from the Publisher

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱 Thank you to our sponsors:EVY - Go to https://www.optoceutics.com/perlmutter  to get 10% off & free shipping (90 days risk-free).Memory Air - Go to www.memoryair.com and use code PERLMUTTER for 15% off, free shipping and a 60-day money back guarantee.====Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available! Discover how to protect your brain and future health - grab your copy today at https:/www.braindefenders.com.====Recent headlines surrounding a reported case of ALS reversal have captured global attention and raised profound questions about what may be possible in the treatment of neurodegenerative disease.In this episode of The Empowering Neurologist, Dr. David Perlmutter examines the work of Dr. M. Marc Abreu, founder and chief medical officer of the BTT Medical Institute. Trained in medicine, biomedical engineering, and medical physics, Dr. Abreu’s work sits at the intersection of neurology, thermodynamics, and computational biology. During his time at Yale, he identified the brain thermoregulatory tunnel, an insight that helped lay the foundation for his current research into brain temperature and neurological disease.Dr. Abreu’s recently published case report describes a patient with documented, progressive ALS who reportedly experienced a dramatic clinical and electrophysiological reversal following a novel, AI-guided, brain-directed thermofebrile intervention.The implications are extraordinary, but so is the need for careful scientific scrutiny. A single case report cannot establish that a treatment is effective, much less prove a cure. What it can do is raise important questions and potentially point researchers toward biological mechanisms worthy of further investigation.00:00 — Can ALS Really Be Reversed?02:32 — A Bold Claim: Treating ALS With Brain Hyperthermia03:42 — Dr. Marc Abreu’s Remarkable Medical Journey10:00 — The Brain’s Language Is Thermodynamics11:54 — The 100-Year-Old Treatment That Inspired a New Approach13:36 — TDP-43 and the Molecular Signature of ALS15:46 — Why the Fever Cycle May Be the Key16:41 — How Brain Temperature Technology Was Developed20:04 — The ALS Patient Who Underwent the Treatment20:57 — Kent’s ALS Diagnosis and Rapid Decline24:31 — 12 Hyperthermia Treatments: What Happened?26:00 — Measuring the Results: Did His Symptoms Improve?28:32 — A Neurologist Witnesses Kent’s Recovery29:49 — How Kent Found Dr. Abreu’s Treatment32:42 — A Mayo Clinic ALS Case and the Evidence37:48 — Could ALS Ever Resolve Spontaneously?39:39 — Are Other ALS Patients Seeing Similar Results?40:13 — Why Is Mainstream Neurology Skeptical?43:51 — Kent on Living With an ALS “Death Sentence”46:56 — From Struggling to Functioning Again47:37 — What Would It Take to Change Neurology?49:57 — How to Learn More About the Treatment51:27 — The Mosquito, Malaria, and the Brain52:26 — Could This Have Implications Beyond ALS?54:22 — What This Could Mean for the Future of Neurodegeneration56:31 — EndDr. M. Marc Abreu is a physician and physicist specializing in brain thermodynamics, thermoregulation, and neurological health. He is the Medical Director of the BTT Medical Institute and is internationally recognized for his discovery of the Brain Thermal Tunnel (BTT), a thermophysical pathway connecting the eyelids to the hypothalamus.Instagram: davidperlmutterWebsite: https://www.drperlmutter.com/Subscribe to our channel: @davidperlmuttermd

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