The Dr. Geo Prostate Podcast

Therapeutic Estrogen for Prostate Cancer: Hot Flashes & Better Sleep | Dr. Richard Wasserbug

September 18, 2026·59 min
Episode Description from the Publisher

What if one of the hardest parts of androgen deprivation therapy is not simply low testosterone—but the loss of estradiol that comes with it?Dr. Richard Wassersug brings a rare dual perspective to that question.He is a PhD evolutionary biologist, former professor of anatomy and neurobiology, prostate cancer quality-of-life researcher, co-developer of an androgen deprivation education program, and a patient who has used transdermal estradiol for more than two decades. His experience helped drive a deeper investigation into whether estrogen delivered through the skin could suppress testosterone while avoiding some of the burdens associated with standard LHRH-based ADT.In this episode, you’ll learn:🟠 Why men need estradiol for **brain, bone, sexual, and overall health.**🟠 What the **PATCH research** suggests about transdermal estradiol, cancer control, and quality of life.🟠 Why **hot flashes, poor sleep, fatigue, and cognitive symptoms** may reflect more than testosterone loss.🟠 What men should know about **gynecomastia, monitoring, exercise, and shared decision-making** before considering this emerging strategy.decision-making before considering this emerging strategy.Chapters 00:00 ADT Side Effects Question00:54 Podcast Disclaimers01:33 Meet Dr Wassersug03:59 Diagnosis And Early Treatment04:58 Finding Estradiol Research07:29 Lupron Side Effects And Sleep08:48 Why Men Need Estradiol11:00 Switching To Estradiol15:13 NEJM Patch Trial Breakdown20:53 Gynecomastia And Management24:07 Real World Patient Stories25:20 Sponsor Message Break27:51 Access Barriers And Limits29:03 ADT Protocols and Sleep31:32 Estradiol Targets and Ratios37:23 Patch vs Gel Dosing39:10 Combining ADT With Estradiol42:52 Who Benefits Most44:18 PATCH Study Scope and Add-Ons47:33 Getting Estradiol Prescribed50:23 Suffering Mindset and Sexual Health54:48 Active Surveillance Trial Ideas___________________________________💪 Exclusive MembershipWant deeper insights? Join The Dr. Geo Prostate Podcast Exclusive Membership for curated transcripts, detailed show notes, expert resources, and member perks. → https://drgeo.com/membership___________________________________📌 Follow and Connect📺 YouTube → Dr. Geo Prostate Podcast — https://www.youtube.com/@DrGeoProstatePodcast🎧 All Episodes → Captivate.fm Archive — https://dr-geo-prostate-podcast.captivate.fm📸 Instagram → https://bit.ly/DRGEO-INSTA-YT📘 Facebook → https://bit.ly/POD-FB-DrGeo💼 LinkedIn → https://bit.ly/DRGEO-LINKEDIN-YT🛒 Supplements → XY Wellness https://bit.ly/3uJPC7Z | Mr. Happy https://bit.ly/3TE7tWE🌐 DrGeo.com Website → https://bit.ly/43khht0___________________________________📣 Hashtags#DrGeoProstatePodcast #ProstateHealth #ProstateCancer #MensHealth #IntegrativeUrology #Urology___________________________________⚠️ DisclaimerThis podcast is for educational purposes only and not medical advice. The views expressed are Dr. Geo’s and not those of his employer(s) or affiliated organizations. Use of this content is at your own risk. Geovanni Espinosa, N.D., assumes no liability for direct or indirect consequences, including economic loss, injury, illness, or death.

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