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The Climate Biotech Podcast

Reimagining Bioreactors to Solve Manufacturing Bottlenecks with Brian Heligman

December 10, 2025·59 min
Episode Description from the Publisher

Biomanufacturing doesn’t fail for lack of clever biology; it stalls at the factory gate. We sit down with Biosphere CEO Brian Heligman to unpack how a materials scientist’s journey through batteries and perovskites led to a bold thesis for the bioeconomy: change the constraints of the bioreactor and you change everything downstream. Instead of miles of steam lines and fragile commissioning, Biosphere is betting on UV-sterilized stainless systems, modern automation, and a full-stack approach t...

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