A Scientific Review on Treatment of Pediatric Gender Dysphoria

Join biochemist Fazale “Fuz” Rana and OB/GYN Christina Cirucci as they discuss discoveries with theological and philosophical implications that point to the reality of God’s existence. In 2025, the US Department of Health and Human Services published a comprehensive, peer-reviewed, 400-page review titled “Treatment for Pediatric Gender Dysphoria: Review of Evidence and Best Practices.” They used rigorous evidence-based medicine methodology and reached the following conclusions: Quality of evidence: The overall quality of evidence concerning the effects of puberty blockers, cross-sex hormones, and surgeries on psychological outcomes, quality of life, or long-term health in minors is very low. Therapeutic benefits: Evidence does not support the effectiveness of these interventions in children and adolescents. Treatment harms: There are known and plausible harms to these treatments—infertility, sexual dysfunction, loss of bone density, adverse cognitive effects, CV disease and metabolic disorders, psych disorders, surgical complications, and regret. Risk-benefit analysis: The evidence demonstrates an unfavorable risk-benefit profile for medical and surgical interventions in children and adolescents with gender dysphoria. These findings are consistent with a biblical ethic that sees biological sex as God's created design and seeks compassionate psychological treatment of gender dysphoria. LINKS AND RESOURCES: Treatment for Pediatric Gender Dysphoria: Review of Evidence and Best Practices A Scientific and Medical Evaluation of Transgenderism Transgenderism and the Bible