Shirtloads of Science

Why Weight Loss Drugs Don't Last Without Lifestyle Change With Dr. Nick Fuller

June 27, 2026·24 min
Episode Description from the Publisher

I'm joined by Dr Nick Fuller to dissect the long-term effectiveness of weight loss medications and why lasting results do actually require more than medication alone. Nick explains why evidence-based behavioural weight management programs remain the first-line approach to weight loss built on three key pillars: diet, exercise and sleep (did you even know that sleep plays a big role in regulating hunger hormones?!) Drawing on his team's research, Nick shares why many people regain weight after stopping medication and why behavioural change is essential for sustainable success (and keeping weight off for good!)

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