Science@UH

Protecting Memory After TBI and in Alzheimer’s – New Hope from 15-PGDH

August 20, 2026·21 min
Episode Description from the Publisher

Discover how a target identified in colon cancer research led to an unexpected opportunity to protect brain cells and preserve cognition in mouse models of Alzheimer’s and head trauma. Sanford Markowitz, MD, PhD, and Andrew Pieper, MD, PhD, describe the translational path, mechanistic insights into neuroinflammation and neurogenesis, and what’s needed for human trials.Learn more about Daniel Simon, MDLearn more about Andrew Pieper, MD, PhDLearn more about Sanford Markowitz, MD, PhDView our Science@UH video podcast on YouTubeLearn more about the University Hospitals Research & Education Institute

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