Dr. Hoelz: Architecture of the cytoplasmic nuclear pore

In this enlightening episode, we welcome the renowned scientist Dr. Hoelz, who has dedicated his life to studying the architecture and function of the Nuclear Pore Complex (NPC). We delve into his groundbreaking research on the cytoplasmic face of the NPC, which plays a pivotal role in the transport of proteins and nucleic acid complexes. Using advanced techniques such as biochemical reconstitution and cryo-electron tomography, Dr. Hoelz and his team have elucidated the near-atomic structure of this critical component of the cell. He talks about his surprising findings, including the heterohexameric cytoplasmic filament nucleoporin complex and the role of NUP358 in efficient translation. Dr. Hoelz further discusses the potential implications of these discoveries on understanding diseases related to nucleoporin mutations and viral virulence factor interference with NPC function. This episode is a treasure trove of insights for those interested in the intricate molecular dynamics within our cells. DOI: 10.1126/science.abm9129