Monoamine Oxidase Inhibitors – Test Prep and Practice Pearls

In this episode, we explore monoamine oxidase inhibitors (MAOIs), one of the oldest yet most effective classes of antidepressants. We discuss how MAOIs such as phenelzine, tranylcypromine, isocarboxazid, and selegiline work by increasing serotonin, norepinephrine, and dopamine levels in the brain. The episode reviews their unique role in treatment-resistant and atypical depression, key adverse effects, important dietary considerations involving tyramine-containing foods, and potentially serious drug interactions. We also highlight practical clinical pearls to help pharmacists and healthcare professionals safely and effectively use these powerful but often underutilized medications. Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE! Support The Podcast and Check Out These Amazing Resources! NAPLEX Study Materials BCPS Study Materials BCACP Study Materials BCGP Study Materials BCMTMS Study Materials Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated) Guide to Drug Food Interactions (Amazon Best Seller) Pharmacy Technician Study Guide by Meded101