S1, E32 - Matt Truppo, PhD: AI-Driven Drug Discovery at Sanofi

AI in drug discovery has been long on promise and short on delivery. Matt Truppo, Global Head of Research Platforms and Computational R&D at Sanofi, presents a different picture. His team used AI to identify 10+ novel drug targets in 12 months, screen 30 million target combinations in days, and produce AI-designed compounds with 75% synthesizability. But Truppo is equally candid about the gaps: data integration, explainability, and change management remain real barriers. In Part 1 of this two-part conversation, hosts Steve Labkoff and Leon Rozenblit explore what happens when AI moves past pilot projects into core pharmaceutical science.