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- 2 days ago
Winston Weinberg: Speed, Stress, and Better Decisions
Knowledge Project: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- Winston Weinberg is the CEO and co-founder of Harvey, the AI platform built for the legal industry. In this episode, Winston explains how AI is reshaping legal work, why judgment becomes more valuable as routine work gets automated, and how to build the prioritization muscle required to move faster, stay focused, and make better decisions when everything is changing. He also shares the operating principles behind Harvey’s growth: make decisions faster, treat most choices as two-way doors, use stress to build resilience, prioritize the one thing that matters most and the Google Doc that drives it all. Harvey began with a simple test: take real legal questions, run them through GPT-3, and ask experienced lawyers whether they would send the answers with zero edits. On 86 out of 100 questions, three out of three attorneys said yes. This is a conversation about AI, law, speed, resilience, and building in a world where the bar keeps getting higher. ------ Timestamps: “The List” that Powers Winston’s $11B Business How to Say “No” Like a CEO The 3 Principles for Strong Decision-Making How Harvey is Changing the Legal World One Cold Email to Sam Altman that Changed Everything The Demo Strategy that Shocked Investors Advice Winston Didn't Take The Deal that Almost Killed Harvey How to Build Resilience to Failure How Winston Hacks His Stress The Key to Creating a Sense of Urgency on Your Team The Kinds of People Not to Hire at Startups How to Screen for Resiliency in Interviews Winston's Advice for Law Students Would AI Make a Better Lawyer than a Human? The Future of Agent-Powered Law Firms Will AI Cause Law Firms to Shrink? Can AI-Only Law Firms Exist? Why Legal Costs Aren't Going Down Three Principles All Entrepreneurs Need to Follow How Winston Defines Success ------ Newsletter: The Brain Food newsletter delivers actionable insights and thoughtful ideas every Sunday. It takes 5 minutes to read, and it’s completely free. Learn more and sign up at fs.blog/newsletter ------ Follow Shane Parrish: X: https://x.com/shaneparrish Insta: https://www.instagram.com/farnamstreet/ LinkedIn: https://www.linkedin.com/in/shane-parrish-050a2183/ Follow Winston Weinberg LinkedIn: https://www.linkedin.com/in/winston-weinberg/ Harvey: https://www.harvey.ai/blog/author/winston-weinberg ------ Thank you to the sponsors for this episode: +CoinShares: Delivering Reason to Digital Asset Investing. https://coinshares.com/ +Granola AI, The AI notepad for people in back-to-back meetings: https://www.granola.ai/shane Check out the Granola Notes. HeyGen is a message-first AI video platform that helps people and AI agents turn ideas into professional video in minutes. Try for free at https://www.heygen.com/ Join the salty rebellion: https://drinklmnt.com/ Learn more about your ad choices. Visit megaphone.fm/adchoices
- 3 days ago
Sell the Truth
Naval's Podcast and Periscope Sessions: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- 00:00 Be Credible 03:18 "Yes, And" 04:31 Selfish Honesty 05:37 Charisma Is Confidence + Love 07:56 Don't Manage, Lead 11:16 Hunt Together 14:51 Feed Your (Good) Obsessions 18:57 Sell the Truth 21:07 Good Deal or No Deal 23:39 The Age of Nonlinear Returns — Transcript: http://nav.al/sell USVC is a product of AngelList, where we are founders and hold equity.
- 4 days ago
How AI at Alpha School Makes Kids Learn 10x Faster (with Joe Liemandt)
Knowledge Project: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- Joe Liemandt quietly built one of the most successful software empires you’ve never heard of—then reappeared with a $1 billion bet that AI can make kids learn ten times faster and love school more than vacation. At Alpha School, students spend just two hours a day on AI‑driven academics, consistently score in the top 1% on standardized tests, and use the rest of their time to build real‑world life skills: leadership, entrepreneurship, teamwork, and projects they actually care about. There are no lectures, no moving on without mastery, and a very different role for “teachers”—now called guides. Liemandt is the principal of Alpha School and the founder of Trilogy Software and ESW Capital. He dropped out of Stanford to build Trilogy, made the cover of Forbes twice before turning thirty, became the youngest member of the Forbes 400, then vanished from public life for twenty‑five years while quietly becoming one of the most prolific acquirers of software businesses in the world. Now he’s using everything he learned about systems, incentives, and scale to rebuild K–12 from first principles around mastery, motivation, and AI. In this conversation, we cover Joe’s full arc, from sleeping on the floor at Trilogy and being mentored by Jack Welch to deciding that “kids must love school more than vacation” would be a non‑negotiable design principle for Alpha. He explains how the Timeback platform works under the hood, why he’s comfortable streaming student screens to AI in real time, and how he plans to scale this model to a billion kids. You’ll learn: why he thinks the traditional classroom was designed for a narrow slice of students and wastes everyone else’s time, what changes when kids master a year of material in roughly 20–22 hours, how guides coach motivation instead of delivering lectures, and the simple rules he uses to make high‑stakes decisions about people, product, and strategy. ------ Timestamps: What’s Broken in Today’s Education System What Makes Alpha School Different Real Results: 2 Hours of AI, Top 1% Scores Who Gets In The Everyday Classroom Problems Alpha Is Fixing Redefining Mastery: No Moving On Until You “Get It” Can You Actually Change a System This Big? Teaching Through AI Solving the Motivation Problem: Why Kids Love Alpha What Makes a Great Guide Instead of a Traditional Teacher Coaching Kids to Own Their Work (and Their Time) Teaching Life Skills: Leadership, Teams, and Real Projects “You Can Do Hard Things”: Building Grit in the Classroom Streaming Student Screens to AI: How Monitoring Works Effort vs. IQ: What Actually Predicts Success at Alpha Rethinking Physics for High Schoolers with AI After Alpha: What Happens to Graduates? Why You Should Invest in Yourself Lessons from Jack Welch: Mentorship and Management Why Trilogy Didn’t Go Public Physical vs Virtual School: What Kids Actually Need More Paying Kids to Learn: Incentives, Rewards, and Risks What Is Success For You? ------ Newsletter: The Brain Food newsletter delivers actionable insights and thoughtful ideas every Sunday. It takes 5 minutes to read, and it’s completely free. Learn more and sign up at fs.blog/newsletter ------ Follow Shane Parrish: X: https://x.com/shaneparrish Insta: https://www.instagram.com/farnamstreet/ LinkedIn: https://www.linkedin.com/in/shane-parrish-050a2183/ Follow Joe Liemandt: LinkedIn: https://www.linkedin.com/in/liemandt/ Tools to help your kids: Math up to grade 7: https://www.synthesis.com/tutor High School Physics: https://physicsgraph.com Math Grade 8-12: https://www.mathacademy.com ------ Thank you to the sponsors for this episode: +Granola AI, The AI notepad for people in back-to-back meetings: https://www.granola.ai/shane Check out the Granola Notes. +Shopify: https://shopify.com/knowledgeproject Learn more about your ad choices. Visit megaphone.fm/adchoices
- 1 weeks ago
Everything You Know is About to Collapse - David Friedberg - #1084
Modern Wisdom: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- David Friedberg is an entrepreneur, investor, and podcaster. What will the future actually look like? With AI dominating the conversation, cutting through the noise matters more than ever. So what’s really coming, and what will it cost us? Expect to learn why the future if going to be epic even if the cost is high, why the future of tech and AI might be overblown, why we should care about the moon, what AI will actually do to jobs despite Anthropic’s new report, what the future of longevity will look like, why California has turned into a failed state and if David is concerned about the rise of socialism, what David is most excited about right now and much more… Sponsors: See discounts for all the products I use and recommend: https://chriswillx.com/deals Get 35% off your first subscription on the best supplements from Momentous at https://livemomentous.com/modernwisdom Get up to 20% off Timeline powered by Mitopure (now at a lower price) at https://timeline.com/modernwisdom Get up to $350 off the Eight Sleep Pod 5 at https://eightsleep.com/modernwisdom Get 160+ biomarkers tested for just $1/day and save an extra $25 at https://functionhealth.com/modernwisdom Get ChatGPT to explore ideas, solve problems, and learn faster at https://chatgpt.com Timestamps: Why the Future Is Going to Be Epic Who Will Control AI: Big Tech or Everyone? Will Everyone Be Able to Use AI Effectively? Should We Build Factories on the Moon? How AI is Changing the Field of Fusion Could Manufacturing on the Moon Boost Earth’s Economy? The Fight For Power in Space The Science Behind Age Reversal How Close Are We to Age Reversal? Could Living Longer Unlock Human Potential? Why Controlling Superintelligence is Critical Is Embryo Selection the Next AI Arms Race? How Ohalo is Reinventing Agriculture What’s Driving California’s Political Decline? Is Socialism the Worst Idea Ever? Why Modern Society Feels So Pessimistic Extra Stuff: Get my free reading list of 100 books to read before you die: https://chriswillx.com/books Try my productivity energy drink Neutonic: https://neutonic.com/modernwisdom Episodes You Might Enjoy: #577 - David Goggins - This Is How To Master Your Life: lnkfi.re/SN-Goggins #712 - Dr Jordan Peterson - How To Destroy Your Negative Beliefs: lnkfi.re/SN-Peterson #700 - Dr Andrew Huberman - The Secret Tools To Hack Your Brain: lnkfi.re/SN-Huberman - Get In Touch: Instagram: https://www.instagram.com/chriswillx Twitter: https://www.twitter.com/chriswillx YouTube: https://www.youtube.com/modernwisdompodcast Email: https://chriswillx.com/contact - Learn more about your ad choices. Visit megaphone.fm/adchoices
- 3 weeks ago
Martin Shkreli on AI, Pharma, and What Actually Matters
A16z Podcast: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- Erik Torenberg speaks with Martin Shkreli, American investor and businessman, about how he sees the AI landscape, from OpenAI to Anthropic, and what actually matters beyond the hype. They also talk through the future of computing, the limits of “vibe coding,” and why biotech and pharma remain some of the toughest industries to get right. Resources: Follow Martin on X: https://x.com/MartinShkreli Stay Updated:Find a16z on YouTube: YouTubeFind a16z on XFind a16z on LinkedInListen to the a16z Show on SpotifyListen to the a16z Show on Apple PodcastsFollow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
- 3 weeks ago
Alex Karnal - The Trillion-Dollar Health Revolution - [Invest Like the Best, EP.468]
Invest Like the Best: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- My guest today is Alex Karnal. Alex is the co-founder and managing partner of Braidwell, a life sciences investment firm he built after spending 15 years at Deerfield Management. The frame we use throughout the episode is the health stack. Alex talks about how most of the diseases that will claim most of our lives are already addressable with medicines that exist today. We work through the five layers of what a defensive health strategy looks like, why GLP-1 medicines represent the first commercial proof that people are ready to be proactive about their health, and why PCSK9 inhibitors may ultimately be the more important drug class even though they get far less attention. We also get into the science and business of drug discovery itself — why most of the published literature that AI companies are training on cannot be replicated, what it would mean to have a truly agentic scientific lab running 24 hours a day, and why Alex believes we are now on a deterministic curve toward scientific superintelligence in biology. For the full show notes, transcript, and links to mentioned content, check out the episode page here. ----- Become a Colossus member to get our quarterly print magazine and private audio experience, including exclusive profiles and early access to select episodes. Subscribe at colossus.com/subscribe. ----- Ramp’s mission is to help companies manage their spend in a way that reduces expenses and frees up time for teams to work on more valuable projects. Go to ramp.com/invest to sign up for free and get a $250 welcome bonus. ----- Trusted by thousands of businesses, Vanta continuously monitors your security posture and streamlines audits so you can win enterprise deals and build customer trust without the traditional overhead. Visit vanta.com/invest. ----- WorkOS is a developer platform that enables SaaS companies to quickly add enterprise features to their applications. Visit WorkOS.com to transform your application into an enterprise-ready solution in minutes, not months. ----- Rogo is the AI platform for finance. They're building agents for Wall Street that are trained to understand how bankers and investors actually do work: from diligence and modeling, to turning analysis into deliverables. To learn more, visit rogo.ai/invest. ----- Ridgeline has built a complete, real-time, modern operating system for investment managers. It handles trading, portfolio management, compliance, customer reporting, and much more through an all-in-one real-time cloud platform. Visit ridgelineapps.com. ----- Editing and post-production work for this episode was provided by The Podcast Consultant (https://thepodcastconsultant.com). Timestamps: Welcome to Invest Like the Best Intro: Alex Karnal State of the Union: GLP1s and Life Sciences The Health Stack Framework Breaking Down the 5 Defensive Layers GLP-1: What's Driving the Inflection Diet vs. Drugs: Is Food Enough? Barriers to Access: Complexity, Cost & Compliance PCSK9: The Closest Thing to a Free Lunch Alzheimer's & Neurodegenerative Disease Cancer: Early Detection & New Treatments Body Imaging & Diagnostic Trade-offs How Drugs Are Discovered AI in Drug Discovery The Automated Lab of the Future Peptides & Citizen Pharmacology Alex's Background Braidwell's Investment Approach The Kindest Thing
- Apr 15, 2026
Hard truths about building in the AI era | Keith Rabois (Khosla Ventures)
Lenny's Podcast: Product | Growth | Career ✓ Claim : Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- Keith Rabois was an early executive at PayPal (part of the famous PayPal Mafia), COO at Square, VP of Corporate Development at LinkedIn, and an early investor in Stripe, DoorDash, Airbnb, YouTube, Ramp, and Palantir. Currently he’s managing director at Khosla Ventures. Also, he hasn’t touched a computer since September 2010 (he does everything from an iPad).In our in-depth conversation, Keith shares:1. The barrels vs. ammunition hiring framework (and how to spot barrels)2. Why talking to customers is actively harmful for consumer products3. How to identify undiscovered talent4. Why the PM role is dying5. The three traits of the best-performing companies right now6. The specific interview question he asks every senior candidate7. Why CMOs (not engineers) are becoming the #1 consumer of tokens—Brought to you by:WorkOS—Modern identity platform for B2B SaaS, free up to 1 million MAUsVanta—automate compliance, manage risk, and accelerate trust with AI—Episode transcript: https://www.lennysnewsletter.com/p/hard-truths-about-building-in-the-ai-era—Archive of all Lenny's Podcast transcripts: https://www.dropbox.com/scl/fo/yxi4s2w998p1gvtpu4193/AMdNPR8AOw0lMklwtnC0TrQ?rlkey=j06x0nipoti519e0xgm23zsn9&st=ahz0fj11&dl=0—Where to find Keith Rabois:• X: https://x.com/rabois• LinkedIn: linkedin.com/in/keith• Website: https://www.khoslaventures.com—Where to find Lenny:• Newsletter: https://www.lennysnewsletter.com• X: https://twitter.com/lennysan• LinkedIn: https://www.linkedin.com/in/lennyrachitsky/—In this episode, we cover: Introduction to Keith Rabois Why Keith hasn’t used a computer since 2010 The team you build is the company you build How Keith learned to identify talent at PayPal Tactics for getting better at hiring The barrels vs. ammunition framework What makes someone a barrel How to attract the best talent Building companies on undiscovered talent Why better performance requires more pressure Career advice in the age of AI The future of the product triad Why design and code are merging What practicing law taught Keith about entrepreneurship Contrarian takes on customer feedback Identifying great AI opportunities Advice for evaluating statrups Criticizing in public vs. private Failure corner Lightning round—Referenced:• Square: https://squareup.com• Jack Dorsey on X: https://x.com/jack• Head of Claude Code: What happens after coding is solved | Boris Cherny: https://www.lennysnewsletter.com/p/head-of-claude-code-what-happens• Simon Willison’s Weblog: https://simonwillison.net• Vinod Khosla on X: https://x.com/vkhosla• Peter Thiel on X: https://x.com/peterthiel• Max Levchin on X: https://x.com/mlevchin• David Sacks on LinkedIn: <a target="_blank" href="https://www.linkedin.com/i
- Mar 29, 2026
The 3 Signs of Human Genius • Leonardo da Vinci's Annunciation (Video)
Creative Codex: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- Discover the 3 Signs of Genius through a journey into the mind of Leonardo da Vinci. What made Leonardo so brilliant? We will venture deeper than anyone else to find out through the most comprehensive analysis of Leonardo da Vinci's first masterpiece: Annunciation.Support the Creative Codex vision and get access to exclusive episodes (Kurt Cobain, Jung's Red Book, Creativity Tips, etc.) by joining my Patreon: https://www.patreon.com/c/mjdorianCreator's Note: No A.I. was used in the production of this video. This includes: no image generation, no text generation, and no music generation. ALL of the art imagery was made by human artists and is credited accordingly throughout the video on the lower right side of the screen. All research, writing, and music is by MJDorian with no assistance from generative A.I. at any point in the production process.Audio Editor: Erik TexterAnimation: Michael PisanoConnect with Michael Pisano: https://www.michaeljamespisano.com/ Instagram: https://www.instagram.com/papa_pisanoInstagram: https://www.instagram.com/thatmakesmesadWritten & Produced by MJDorianMusic by MJDorianConnect with MJDorian:Instagram: https://www.instagram.com/mjdorianYouTube: https://youtube.com/@creativecodex?si=To9hmuUQmuPlb8gNCopyright 2026All rights reserved.
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