
To kick off Season 5, Dani and LC discuss a recent perspective published in the Journal of Organic Chemistry that highlights innovations in synthetic chemistry which trace their origins to the work of discovering, developing and commercializing novel therapeutics. This publication was the most accessed paper published in JOC in 2025!Dani and LC explore the motivations on writing it, its main thesis and lesson learned from reexamining nearly 75 years of chemistry innovations at Merck. Be sure to listen through to the very end for a special Season 5 theme reveal!Read and listen to some of the papers we discussed today:From Cortisone to Enlicitide: A Journey of Synthetic Chemistry Innovations at MerckFollow the Pharm to Table podcast on X - @PharmtoTablePodVisit our website at https://podcasters.spotify.com/pod/show/pharm-to-table
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SE4:E8: From Discovery to Process, Part 2: Getting Ugi with it - scaling a 3CL protease inhibitor

SE4:E7: From Discovery to Process, Part 1: Building a 3CL Protease Inhibitor Through Smart Fluorine Placement and Design Intuition

SE4:E6 - Mechanism-Driven Innovation in Process Research: Yining Ji Chen’s Road as a Rising Star

SE4:E5 - Evolution of a Green Chemistry Trailblazer
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