The Science of Ozempic and GLP-1 Medications | Dr Tom Buckley

Inside the venom of a desert lizard, scientists found a molecule that does something the diet industry spent 50 years failing to do. It quietly switches off hunger. That molecule is now the most talked about drug on the planet, and it's sitting in the fridges of millions of people who couldn't explain how it works if you paid them.Dr Tom Buckley, 30 years in medicine and a professor at Sydney University, has looked at the evidence and called these drugs revolutionary.But what about "Ozempic face"? What if the wait comes back after you stop? Who should never touch these drugs? Dr Tom and Andrew get into the science so you finally have all the answers you need. 00:00 – A desert lizard that eats twice a year 03:32 – What a GLP-1 actually is, in plain English 07:36 – Ghrelin and leptin: hunger and fullness, explained 10:23 – The venom that cracked the hunger code 14:06 – Why your body is built to hold onto fat 15:19 – How to raise GLP-1 without a prescription 18:10 – Become the CEO of your body and brain 22:10 – You don't lose fat cells, they shrink 24:39 – "Ozempic face," and why you lose weight slowly 28:17 – The "Limitless" effect: cognitive horsepower 29:28 – 76 trials, 40,000 patients: the evidence 30:47 – Lancet 2024: heart attacks and strokes down 32:11 – Why Tom calls these drugs regenerative 34:18 – Who should never take it 35:23 – The side effects nobody mentions upfront 41:19 – On it and off it: what you have to get right 48:14 – Most regain 75% within a year of stopping 50:09 – Metabolic rebound: worse than where you started 52:51 – The hidden economy GLP-1s are reshaping 56:13 – Tom's cliff notesYou can find Dr Tom at his LinkedIn: https://www.linkedin.com/in/tom-buckley-06a76b98/ Use Code "PQPODCAST10" to get 10% off your Lumo Coffee order:https://lumocoffee.com/ Interested in sharing your story? Email Producer Shannon at support@performanceintelligence.com today with your story and contact details. Learn more about Andrew and Performance Intelligence: https://performanceintelligence.com/Find out more about Andrew's Keynotes : https://performanceintelligence.com/keynotes/Follow Andrew May: https://www.instagram.com/andrewmay/Watch the Performance Intelligence Podcast on Youtube: https://www.youtube.com/@performanceintelligencepodcastIf you enjoy the podcast, we would really appreciate you leaving a short review on Apple Podcasts, Spotify or Google Play. It takes less than 60 seconds and really helps us build our audience and continue to provide high quality guests.