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Nuance Needed

105: Depression, Anxiety, and the Myth of the Chemical Imbalance

March 31, 2026·46 min
Episode Description from the Publisher

What if the entire “chemical imbalance” story about depression was oversimplified… and it’s actually keeping you stuck?In conversation, we tackle: The 2022 study that “debunked” serotonin—and why everyone completely overreacted to it How Big Pharma accidentally sold us an oversimplified story (because it was easier to market) The anxiety → over-functioning → burnout → depression crash cycle (and why so many high-achievers are stuck in it) Why “just think positive” might actually be making your depression worse The brutal reality: the things that help depression are the exact opposite of what you feel like doing Why chasing happiness is setting you up to feel worse—and what to aim for instead If you’d like to support the show one of the best things you can do is leave us a review and share the pod! THANK YOU!We have some incredible BONUS episodes on our SUBSTACK! nuanceneeded.substack.comTo learn more about therapy reach out to Therapy for Women Center, therapyforwomencenter.com. We have therapists licensed in 42 states across the country and have offices if you are local to the Philadelphia area.Want to join the conversation? You can email us podcast@therapyforwomencenter.com. We’d love to hear what you think!

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