Midlife Conversations with Natalie Jill: Fat Loss, Hormones & Health for Women Over 40

553: We Lose 30% of Our Collagen in the First 5 Years of Menopause. Here Is What to Do. with Dr. Alessandra Zonari

October 6, 2026·1h 4m
Episode Description from the Publisher

Menopause hits our metabolism, our bones, our brain. What we do not talk about is that it hits the actual biology of our skin too. In the first 5 years of menopause we can lose 30 percent of our collagen. We lose hyaluronic acid. We lose elastin. Our skin does not just get drier. The scaffolding that HOLDS moisture in, falls apart. My guest today calls this the density shift, and this is the education episode midlife women have been waiting for. Dr. Alessandra Zonari is a skin longevity scientist trained in tissue engineering and stem cell biology. She was on the show before to break down senescent cells, the zombie cells that drive skin aging. Today we go deeper. Menopause skin. Why our rich cream stopped working. Why we cannot moisturize our way out of this. And what actually addresses skin at the biology level. If our skin has started feeling unfamiliar, this episode is going to explain WHY and what to do about it. WHAT WE COVER •  Why women in their 40s and 50s feel their skin suddenly feels unfamiliar •  What is actually happening to skin when estrogen drops •  The density shift and the numbers behind it •  Why rich creams stopped working after menopause •  The bricks and mortar of skin hydration •  Skin's natural moisturizing factor and why it declines •  Zombie cells and how they collide with menopause •  Skin's biological age vs chronological age •  What to look for in a peptide that actually works •  Where skin longevity fits into HRT, strength training, and sleep   TRY ONESKIN'S RICHEST INNOVATION YET Head to https://oneskin.co/NatalieJill  and use code NATALIEJILL for 15% off OS-01 RICH CREAM, engineered specifically for menopausal skin.   Catch the full episode on YOUTUBE HERE: https://bit.ly/MidlifeConversationsYouTube    Learn More About Dr. Alessandra Zonari and OneSkin Instagram ➜ https://www.instagram.com/oneskin.co  Website ➜ https://shop.oneskin.co/nataliejill    Thank you to our show sponsors:  SUNLIGHTEN SAUNA:  Sleep better. Recover faster. Stress less. Get Sunlighten infrared saunas HERE https://sunlighten.com  and use code NATALIEJILL to save up to $1,400!  Free Gifts for being a listener of Midlife Conversations! Mastering the Midlife Midsection Guide: https://theflatbellyguide.com/ Age Optimizing and Supplement Guide: https://ageoptimizer.com   Connect with me on social media! Instagram: www.Instagram.com/Nataliejllfit Facebook: www.Facebook.com/Nataliejillfit   For advertising inquiries: https://www.category3.ca/  Disclaimer: Information provided in the Midlife Conversations podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease

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