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- Mar 26, 202644 min
W.H.O. Long COVID Exclusive
Dr Funmi Okunola MD conducts three interviews with 4 representatives of the World Health Organization -Dr Maria Van Kerkhove PhD -Director of the Department of Epidemic & Pandemic Threat Management;Dr Jamie Rylance MD - Clinical Lead for Long COVID and part of the Clinical Management Team of the Health Emergencies Program;Cristiana Salvi - Regional Advisor for Community Resilience & Protection in the Health Security Division of WHO Europe;Leonardo Palumbo - Technical Officer in Community Engagement in the Health Security Division of WHO Europe.We talk about the WHO's support of Long COVID through advocacy, education research and community engagement and the steps the organization is taking to ensure Worldwide equity with regard to access to health resources for those living with Long COVID.REFERENCES:The World Health Organization WebsiteThe WHO declares COVID-19 a Public Health Emergency of International Concern on 30th Jan 2020The WHO declares COVID-19 a Pandemic on the 11th March 2020Dr Maria Van Kerkhove's Speech at the UBC Centre of Disease Control Global Health Security Summit in Vancouver Canada on 5th Nov 2025WHO Mythbusters - 30th Jan 2026-31st March 2026
- Jan 11, 202517 min
Episode 28 - Long COVID Research & Potential Treatments Part 2– with Professor David Putrino
Professor David Putrino is a physiotherapist with a PhD in Neuroscience. He is currently the Director of Rehabilitation Innovation for the Mount Sinai Health System, and a Professor in the Department of Rehabilitation and Human Performance at the Icahn School of Medicine at Mount Sinai. Professor Putrino recently opened the Mount Sinai Cohen Center for Recovery from Complex Chronic Illness in New York also known as (CoRE) and serves as CoRE’s Family Director and is also a member of PolyBio’s Long COVID Research Consortium.Today's episode is the second in a two part series looking at research into potential treatments for Long COVID.REFERENCES1 Polybio Article - A clinical trial of repurposed HIV antivirals in Long COVID2 Patterson BK, Yogendra R, Guevara-Coto J, Mora-Rodriguez RA, Osgood E, Bream J, Parikh P, Kreimer M, Jeffers D, Rutland C, Kaplan G. Case series: maraviroc and pravastatin as a therapeutic option to treat long COVID/Post-acute sequelae of COVID (PASC). Frontiers in Medicine. 2023 Feb 8;10:1122529.3 Polybio Article - Long COVID low-dose rapamycin clinical trial4 Polybio Article - Lumbrokinase Long COVID & ME/CFS clinical trial
- Jan 4, 202531 min
Episode 27 - Long COVID Research & Potential Treatments Part 1 – with Professor David Putrino PhD
Professor David Putrino is a physiotherapist with a PhD in Neuroscience. He is currently the Director of Rehabilitation Innovation for the Mount Sinai Health System, and a Professor in the Department of Rehabilitation and Human Performance at the Icahn School of Medicine at Mount Sinai. Professor Putrino recently opened the Mount Sinai Cohen Center for Recovery from Complex Chronic Illness in New York also known as (CoRE) and serves as CoRE’s Family Director and is also a member of PolyBio’s Long COVID Research Consortium.Today we talk about the pathophysiology of Long COVID in the context of describing research into targeted treatments for the disease.REFERENCES1 Proal AD, VanElzakkerMB, Aleman S, Bach K, Boribong BP, Buggert M, Cherry S, Chertow DS, Davies HE, Dupont CL, Deeks SG. SARS-CoV-2 reservoir in post-acute sequelae of COVID-19(PASC). Nature Immunology. 2023 Oct;24(10):1616-27.2 Klein J, Wood J,Jaycox JR, Dhodapkar RM, Lu P, Gehlhausen JR, Tabachnikova A, Greene K, Tabacof L, Malik AA, Silva Monteiro V. Distinguishing features of Long COVID identified through immune profiling. Nature. 2023 Nov 2;623(7985):139-48.3 Long COVID low-dose Rapamycin clinical trial4 Lumbrokinase LongCOVID & ME/CFS clinical trial5 Silva J, Takahashi T, Wood J, Lu P, Tabachnikova A, Gehlhausen JR, Greene K,Bhattacharjee B, Monteiro VS, Lucas C, Dhodapkar RM. Sex differences insymptomatology and immune profiles of Long COVID. medRxiv. 2024 Mar 2:2024-02.6 VanElzakker MB, Bues HF, Brusaferri L, Kim M, Saadi D, Ratai EM, Dougherty DD, Loggia ML. Neuroinflammation in post-acute sequelae of COVID-19 (PASC) as assessed by [11C] PBR28 PET correlates with vascular disease measures. Brain, Behavior, and Immunity.7 Fernández-CastañedaA, Lu P, Geraghty AC, Song E, Lee MH, Wood J, O’Dea MR, Dutton S, Shamardani K, Nwangwu K, Mancusi R. Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation. Cell. 2022 Jul 7;185(14):2452-68.
- Dec 28, 202443 min
Episode 26 - A Potential Treatment & Biomarker for Long COVID with Professor Nancy Klimas
Professor Nancy Klimas is interviewed about the mechanisms behind how a nebulised medication caused a remarkable recovery from symptoms of ME/CFS and Long COVID in a small group of individuals and her objective to gain the ability to extend this research into a larger population of people with the hope of finding a viable treatment for these diseases.REFERENCES1 Gil A, Hoag GE, Salerno JP, Hornig M, Klimas N, Selin LK. Identification of CD8 T-cell dysfunction associated with symptoms in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and Long COVID and treatment with a nebulized antioxidant/anti-pathogen agent a restropective case series.2 Long COVID the Answers Episode 6:“PEM, Long COVID & It’s Management featuring Professor Todd Davenport”3 Appelman B, Charlton BT, Goulding RP, Kerkhoff TJ, Breedveld EA, Noort W, Offringa C,Bloemers FW, van Weeghel M, Schomakers BV, Coelho P., Wüst Rob.C Muscle abnormalitiesworsen after post-exertional malaise in long COVID. Nature communications. 2024Jan 4;15(1):1-54 Oldham WM, Lewis GD, Opotowsky AR, Waxman AB, Systrom DM. Unexplained exertional dyspnea caused by low ventricular filling pressures: results from clinical invasive cardiopulmonary exercise testing. Pulm Circ. 2016 Mar;6(1):55-62. 5 Joseph P, Arevalo C, Oliveira RKF, Faria-Urbina M, Felsenstein D, Oaklander AL, Systrom DM. Insights From Invasive Cardiopulmonary Exercise Testing of Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Chest. 2021 Aug;160(2):642-651. 6 Singh I, Joseph P, Heerdt PM, Cullinan M, Lutchmansingh DD, Gulati M, Possick JD, Systrom DM, Waxman AB. Persistent Exertional Intolerance After COVID-19: Insights From Invasive Cardiopulmonary Exercise Testing. Chest. 2022 Jan;161(1):54-63. 7 Joseph P, Pari R, Miller S, Warren A, Stovall MC, Squires J, Chang CJ, Xiao W, Waxman AB, Systrom DM. Neurovascular Dysregulation and Acute Exercise Intolerance in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Placebo-Controlled Trial of Pyridostigmine. Chest. 2022 Nov;162(5):1116-1126. 8 Open Medicine Foundation: Dr. David Systrom Discusses OMF's LIFT Clinical Trial
- Dec 21, 202436 min
Episode 25 - Mast-Cell Activation Syndrome & Long COVID with Dr David Lyons Kaufman MD
Dr David Lyons Kaufman is interviewed about Mast Cell Activation Syndrome. Dr Kaufman is a working member of the U.S. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Clinical Coalition and part of the Guideline Committee. He is a founder and practising physician of the Center for Complex Diseases based in Seattle and California, USA which has a focus on patients suffering from Complex Chronic Disease such as Mast Cell Activation Syndrome ME/CFS & Long COVID.REFERENCEAfrin LB, Ackerley MB, Bluestein LS, Brewer JH, Brook JB, Buchanan AD, Cuni JR, Davey WP, Dempsey TT, Dorff SR, Dubravec MS. Diagnosis of mast cell activation syndrome: a global “consensus-2”. Diagnosis. 2021 May 1;8(2):137-52.
- Dec 14, 202438 min
Episode 24 - The Patient-Led Research Collaborative Part 2 with Gina Assaf & Letícia Soares
Gina Assaf & Letícia Soares are interviewed about the work they do as part of the Patient-Led Research Collaborative. In this episode we do a deep dive into their latest publication.REFERENCES1 Soares L, Assaf G, McCorkell L, Davis H, Cohen A, Moen J, Shoemaker L, Liu L, Lewis D, Robles R, McWilliams C. Long COVID and associated outcomes following COVID-19 reinfections: Insights from an InternationalPatient-Led Survey.
- Dec 7, 202420 min
Episode 23 - Are Monoclonal Antibodies a Possible Treatment for Long COVID? With Professor Nancy Klimas
Dr Funmi Okunola MD interviews Professor Nancy Klimas MD about her research into the use of Monoclonal Antibodies as a possible treatment for Long COVID. We have an exciting and exclusive breaking news item in this episode!REFERENCES1 Scheppke KA, Pepe PE, Jui J, Crowe RP, Scheppke EK, Klimas NG, Marty AM. Remission of severe forms of long COVID following monoclonal antibody (MCA) infusions: a report of signal index cases and call for targeted research. The American Journal of Emergency Medicine. 2024 Jan 1;75:122-7.2 Zuo W, He D, Liang C, Du S, Hua Z, Nie Q, Zhou X, Yang M, Tan H, Xu J, Yu Y. The persistence of SARS-CoV-2 in tissues and its association with long COVID symptoms: a cross-sectional cohort study in China. The Lancet Infectious Diseases. 2024 Apr 22.3 Hope & Help for Fatigue and Chronic Illness - The Institute For Neuro-Immune Medicine Podcast4 Appelman B, Charlton BT, Goulding RP, Kerkhoff TJ, Breedveld EA, Noort W, Offringa C,Bloemers FW, van Weeghel M, Schomakers BV, Coelho P., Wüst Rob.C Muscle abnormalitiesworsen after post-exertional malaise in long COVID. Nature communications. 2024Jan 4;15(1):1-5
- Nov 30, 202429 min
Episode 22 – Patient-Led Research Collaborative Part 1– Lisa McCorkell, Gina Assaf & Letícia Soares
Three members of the Patient-Led Research Collaborative - Lisa McCorkell, Gina Assaf & Letícia Soares are interviewed by Dr Funmi Okunola about the organisation and the work it does.REFERENCES1 The Patient-Led Research Collaborative Website2 The Patient-Led Research Collaborative Donation Page3 Portela MC et al. 2024. Protocol for an ambidirectional cohort study on long COVID and the healthcare needs, use and barriers to access health services in a large city in Southeast Brazi. lBMJ Open 14:e086656.4 Caldas B et al. 2024. Promoting equity, diversity, and inclusion in surveys: insights from a patient-engaged study to assess long COVID health-care needs in Brazil. Journal of Clinical Epidemiology, 173: 111423
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About Long COVID the Answers
A new weekly series all about Long COVID. Dr Funmi Okunola MD interviews a wide range of experts in the field about the disease, its possible causes, the assessment, diagnosis and management and the mechanisms of rehabilitation and recovery from Long COVID.
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