
Our 238th episode with a summary and discussion of last week's big AI news!Recorded on 03/18/2026Hosted by Andrey Kurenkov and Jeremie HarrisFeel free to email us your questions and feedback at andreyvkurenkov@gmail.com and/or hello@gladstone.aiRead out our text newsletter and comment on the podcast at https://lastweekin.ai/In this episode:* OpenAI released GPT-5.4 mini and nano with 400k-token context windows, higher per-token prices but claimed token-efficiency gains in Codex; nano is API-only and pitched for high-volume classification/data extraction despite a major price increase.* Mistral open-sourced the Small 4 model family (MoE, 119B total/6B active) combining reasoning, multimodal, and coding-agent capabilities, and announced Forge to help businesses train or post-train custom models.* Agent “operating system” competition intensified with Meta’s acquired Manus launching a local Mac agent, Nvidia announcing NeMo/“Open Shell” sandboxed agent runtime, and Nvidia also unveiling DLSS 5 plus major hardware forecasts including Groq LPU integration.* Business and safety updates included OpenAI shifting focus toward productivity/enterprise amid competition, Microsoft reorganizing Copilot and frontier-model efforts, Meta delaying its next model, China-linked ByteDance deploying large Nvidia clusters abroad, and new safety work on steganography, chain-of-thought faithfulness, fine-tuning defenses, cyber-attack evals, and constitution/spec compliance.A thank you to our current sponsors:Box - visit Box.com/AI to learn moreODSC AI - go to odsc.ai/east and use promo code LWAI for an additional 15% off your pass to ODSC AI East 2026.Factor - head to factormeals.com/lwai50off and use code lwai50off to get 50 percent off and free breakfast for a yearTimestamps:(00:00:10) Intro / Banter(00:01:56) News PreviewTools & Apps(00:02:39) OpenAI ships GPT-5.4 mini and nano, faster and more capable but up to 4x pricier(00:08:04) Mistral's new Small 4 model punches above its weight with 128 expert modules(00:14:03) Meta's Manus launches 'My Computer' to turn your Mac into an AI agent - 9to5Mac(00:17:57) NVIDIA Announces NemoClaw for the OpenClaw Community | NVIDIA Newsroom + Nvidia boosts knowledge work with Open Agent Development Platform(00:24:09) DLSS 5 looks like a real-time generative AI filter for video games | The Verge(00:26:36) OpenAI to Launch ChatGPT 'Adult Mode' Despite Warnings From Its Own Advisers - CNETApplications & Business(00:33:46) OpenAI Reportedly Pivoting to a Focus on Business and Productivity Only(00:41:25) Nvidia GTC 2026: CEO Jensen Huang sees $1 trillion in orders for Blackwell and Vera Rubin through ’27(00:45:44) Mistral launches Forge to help enterprises build their own AI models<l
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#242 - ChatGPT Images 2.0, Qwen 3.6 Max, Kimi-K2.6

#241 - Opus 4.7, Muse Spark, GPT-5.4-Cyber, HY-World 2.0

#240 - Project Glasswing, Claude Mythos, GLM-5.1, emotion concepts

#239 - RIP Sora, Claude Openclaw, HyperAgents
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