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Inside GRAPPA: Daily Summaries Delivered
by GRAPPA Network
Welcome to Inside GRAPPA, a podcast and brought to you by the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA). Our mission is to enhance understanding and treatment of psoriasis and psoriatic arthritis through the sharing of research, knowledge, and collaborative efforts.We bring together leading rheumatologists, dermatologists, scientists, patient representatives, and industry partners, uniting our passions to make a difference for those living with these conditions.Join our host Fabian Proft as we navigate the challenges, share the latest research, and explore the triumphs in the world of psoriasis and psoriatic arthritis. Together, we can make a difference. Hosted on Acast. See acast.com/privacy f
Latest Episodes
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- 1 weeks ago24 min
Deucravacitinib in Psoriatic Disease
In this episode of Inside GRAPPA, Dr. Andre Lucas Ribeiro, Dr. Anna López Ferrer, and Professor Philip J. Mease explore the role of deucravacitinib, a selective TYK2 inhibitor, in the evolving treatment landscape of psoriatic disease.Together, they examine the unmet needs in psoriasis and psoriatic arthritis, discuss the clinical evidence supporting deucravacitinib's efficacy and safety, and consider its potential place among existing treatment options. The conversation also highlights the importance of individualized treatment decisions, remaining evidence gaps, and future research opportunities.HighlightsExplore ongoing unmet needs in psoriatic arthritis and the importance of expanding oral treatment options.Understand deucravacitinib's unique mechanism of action and how selective TYK2 inhibition differs from traditional JAK inhibitors.Review key findings from the POETYK clinical trials, including efficacy in joint and skin manifestations.Examine the safety and tolerability profile, including insights from long-term psoriasis data.Discuss how deucravacitinib may fit into clinical practice and which patient characteristics may influence treatment selection.Identify remaining research questions, including axial disease, difficult-to-treat PsA, and combination therapies.Look ahead to ongoing studies and future opportunities to advance personalized treatment in psoriatic disease.ConnectStay up to date with the latest psoriatic disease research, GRAPPA initiatives, and future episodes of Inside GRAPPA at grappanetwork.org. Hosted on Acast. See acast.com/privacy for more information.
- Sep 17, 202612 min
Inside the New GRAPPA App: Clinical Tools, Education, and More
The GRAPPA app has been rebuilt from the ground up to become a more complete resource for the psoriatic disease community.In this episode of Inside GRAPPA, host André L. Ribeiro is joined by Daniela Tovar Bastidas and Laura C. Coates to discuss the thinking behind the redesigned app, the year-long collaborative development process, and how the platform has expanded far beyond its original focus on clinical assessment tools.They explore how the new app brings clinical resources, education, research, events, and patient-friendly information together in one place, with tailored experiences for GRAPPA members, healthcare professionals, and patients. The conversation also looks ahead at how tools such as the Diagnostic Ultrasound Enthesitis Tool (DUET), multilingual access, and continued user feedback can help the app evolve alongside the needs of the global psoriatic disease community.HighlightsWhy GRAPPA redesigned the original app around a broader clinical and educational missionBringing assessment tools, research, events, and educational resources into one platformDesigning tailored experiences for GRAPPA members, healthcare professionals, and patientsMaking trusted psoriatic disease information easier to access during clinical practiceThe collaborative development and user-experience process behind the redesignExpanding multilingual access for users around the worldIncorporating clinical resources such as the Diagnostic Ultrasound Enthesitis Tool (DUET)How user feedback will guide future resources and updatesTimestamps1:28 – Why GRAPPA redesigned the original app3:45 – Daniela Tovar Bastidas explains the development process5:36 – How the app serves members, healthcare professionals, and patients8:18 – Supporting daily clinical practice through easier access to GRAPPA resources9:45 – The future of the GRAPPA App and continued expansionResourcesGRAPPA App – Apple App StoreGRAPPA App – Google PlayGRAPPA NetworkDUET Study – GRAPPA NetworkConnectLearn more about GRAPPA and its work in psoriatic disease research, education, and clinical care at grappanetwork.org. Hosted on Acast. See acast.com/privacy for more information.
- Apr 8, 202617 min
Body Composition & Risk in Psoriatic Disease
In this episode, host Dr. Mio Nakamura (University of Michigan) speaks with Dr. Lyn Ferguson (University of Glasgow) about her study on how body composition (not just weight) impacts psoriatic disease and cardiometabolic risk. This study was supported by a GRAPPA Pilot Research Grant.HighlightsObesity is strongly linked to worse psoriasis and psoriatic arthritis outcomesVisceral fat, liver fat, and muscle fat are more important than BMI alonePatients with psoriatic disease show:Higher visceral and ectopic fatLower muscle volumeAdverse muscle composition (low muscle + high fat) is a key risk marker:~3× higher risk of type 2 diabetes2× higher risk of heart diseaseMay also help predict future psoriasis riskConnectStay up to date with the latest in psoriatic disease research and GRAPPA initiatives: https://www.grappanetwork.org Hosted on Acast. See acast.com/privacy for more information.
- Dec 29, 202515 min
Guiding GRAPPA Forward: GRAPPA’s Co-Presidents in Conversation
In this special awards-edition episode of Inside GRAPPA, host Fabian Proft sits down with GRAPPA Co-Presidents Professor Joseph F. Merola and Professor Arthur Kavanaugh. Together they reflect on their first encounters with the organization, the origins and evolution of GRAPPA, and the collaborative culture that continues to shape psoriatic disease research worldwide.Joe and Artie share candid stories from the early days of TNF inhibitor trials, discuss the growing impact of Young GRAPPA, highlight the essential role of patient partners, and look ahead to the next five years of scientific and clinical progress in psoriatic disease.HighlightsJoe and Artie share how they first became involved with GRAPPA and what drew them into psoriatic disease research. Artie reflects on GRAPPA’s early origins, shaped by global collaboration around the first TNF inhibitor studies. GRAPPA’s culture remains defined by openness, interdisciplinary exchange, and highly approachable leadership. Key unmet needs persist, including challenges in under-served psoriasis phenotypes and skin-to-joint progression. Personalized medicine in PsA is still an unmet priority, despite major therapeutic advances. GRAPPA’s future direction focuses on comorbidities, prevention, remission, and strengthening the next generation of leaders. Timestamps00:00 - Welcome & introduction00:52 - Joe's first encounter with GRAPPA01:56 - Artie describes GRAPPA's origins and early collaborations03:26 - What makes GRAPPA's culture unique05:26 - The role of patient partners07:56 - Why Joe and Artie stepped into co-presidency09:52 - Current unmet needs in psoriatic disease11:16 - Personalized medicine and future clinical direction12:18 - GRAPPA's next five years13:16 - How clinicians, researchers, and trainees can get involved Hosted on Acast. See acast.com/privacy for more information.
- Nov 7, 202520 min
Sleep and PsA: Exploring the Hidden Connection
In this episode of Inside GRAPPA, host Dr. Mio Nakamura (University of Michigan) speaks with Dr. Tina Bhutani-Jacques, MD, MAS, FAAD (Synergy Dermatology / University of California San Francisco) about her groundbreaking study on the role of sleep in psoriasis disease severity. Funded by the GRAPPA Pilot Research Grant, Dr. Bhutani-Jacques’s work is the first prospective cohort study to objectively examine sleep patterns in psoriasis patients.💡 Together, they explore:How a patient’s unexpected experience sparked the idea to investigate sleep and psoriasisThe design and findings of the pilot study using three nights of polysomnography in patients and healthy controlsEarly results showing reduced sleep efficiency, more awakenings, and nearly an hour less sleep per night among psoriasis patientsThe potential link between poor sleep, inflammation, and cardiovascular comorbiditiesPractical advice for clinicians on discussing sleep with psoriasis patientsNext steps, including home-based sleep studies using wearables for more naturalistic data🎧 Tune in for an engaging discussion that highlights how sleep—often overlooked—may be a key factor in understanding psoriatic disease and improving patient outcomes. 🔗 Learn more about GRAPPA’s research initiatives at grappanetwork.org. Hosted on Acast. See acast.com/privacy for more information.
- Oct 14, 202520 min
Shaping the Future: Young GRAPPA Leaders on Mentorship, Collaboration, and Growth
In this episode of Inside GRAPPA, host Dr. Hanna Johnsson spotlights the next generation of leaders in psoriatic disease research through a deep dive into the work of Young GRAPPA---a global, interdisciplinary network within GRAPPA, supporting early-career researchers and clinicians.Joining the conversation are Dr. André L. Ribeiro (Chair, Young GRAPPA, Brazil) and Dr. Gizem Ayan (Chair-Elect, Young GRAPPA, Turkey), who share their personal journeys into leadership and reflect on how mentorship, collaboration, and international networking are transforming opportunities for early-career professionals.💡 Together, they discuss:How Young GRAPPA has grown into a +200-member global network since 2021Projects driving impact, from the Slide Library and Do Not Miss newsletter to international webinars and surveysThe power of mentorship, collaboration, and patient partnership in shaping research prioritiesAdvice for early-career clinicians and researchers eager to get involvedDream collaborations and the importance of saying "yes" to opportunities early🎧 Tune in for a conversation filled with practical advice, inspiration, and an open invitation to join Young GRAPPA in shaping the future of psoriatic disease care.🔗 Learn more and apply to join Young GRAPPA at grappanetwork.org. Hosted on Acast. See acast.com/privacy for more information.
- Jun 12, 202513 min
Patient Research Partners: Elevating Research Through Patient Perspectives
In this special episode of Inside GRAPPA, we delve into the growing impact of the Patient Research Partner (PRP) Network—an essential part of GRAPPA’s mission to integrate the patient voice into scientific research on psoriatic disease.Host Fabian Proft is joined by two influential PRPs: Maarten de Wit from the Netherlands and Suzanne Grieb* from the United States. Together, they explore the critical role of PRPs, the evolution of the network since its inception in 2013, and how these dedicated patient collaborators are shaping treatment guidelines, influencing steering committees, and helping recruit the next generation of partners.What does it really mean to live the principle of “Nothing about us without us”? What kinds of challenges—and transformative insights—do patients bring to the research table? And what can researchers learn from patient partners about improving outcomes, communication, and the research agenda itself?Listen in as we discuss:The origins and global growth of the PRP networkReal-world experiences from PRPs living with psoriatic arthritisHow patients are steering research priorities, not just participating in themStrategies for recruiting and onboarding new patient partnersWhere the network is headed—and how you might get involved🎧 Tune in for a powerful conversation that highlights how experiential knowledge and scientific expertise can—and must—work hand in hand.Subscribe to Inside GRAPPA on your favorite podcast platform.Stay tuned. Stay curious.*Suzanne Grieb is engaged in GRAPPA-related activities as a private consultant or advisor and not in their capacity as a Johns Hopkins faculty member. Hosted on Acast. See acast.com/privacy for more information.
- May 16, 202514 min
Defining Difficult-to-Treat and Complex-to-Manage Psoriatic Arthritis
In this compelling episode of Inside GRAPPA, host Dr. Hanna Johnsson, a rheumatologist based in Scotland, leads an important conversation on one of the most pressing issues in psoriatic arthritis (PsA) care: what truly makes a case difficult to treat or complex to manage?Dr. Johnsson is joined by two experts deeply embedded in the GRAPPA initiative to define these concepts:Dr. Fabian Proft, Head of the Division of Rheumatology at Charité Berlin, Germany, and long-time GRAPPA contributor.Dr. Shikha Singla, Assistant Professor of Medicine at the Medical College of Wisconsin, who brings firsthand experience from her combined rheum-derm clinic.Together, they unpack the background, progress, and patient-centered approach of the Difficult-to-Treat (D2T) and Complex-to-Manage PsA Project.✅ HighlightsClearer definitions aim to improve care for patients with persistent symptoms despite treatment“Difficult to treat” focuses on ongoing inflammation; “complex to manage” accounts for non-inflammatory factorsA global literature review revealed inconsistent criteria in defining treatment challengesSurveys of clinicians and patients shaped a more inclusive, consensus-driven frameworkNew definitions to be presented at EULAR—marking a major milestone in PsA research⏱ Timestamps00:00 – Introduction to the episode and today’s topic00:36 – Guest introductions: Dr. Fabian Proft and Dr. Shikha Singla01:00 – Fabian on the need for better definitions and understanding treatment failure04:12 – Defining the terms: inflammation vs. non-inflammatory drivers of disease burden05:15 – Why “complex to manage” is more appropriate than “difficult patient”06:00 – How terminology shapes perceptions and supports more empathetic care06:42 – Scoping literature review: methods and inconsistencies in existing definitions07:57 – Healthcare provider survey: over 200 responses, strong support for two definitions09:12 – Patient survey: nearly 600 responses and insights into global experiences10:21 – Patient-reported challenges: joint pain, fatigue, medication side effects11:54 – Cultural and social factors influencing patient experience12:39 – The Delphi process and achieving expert consensus13:15 – Project milestones: EULAR submission and upcoming publications📚 ResourcesExplore the full scope of this initiative on the GRAPPA D2T PsA Project Page.🔗 Links and Social MediaVisit our Website for more information.Follow us on YouTube, Facebook, and Twitter. Hosted on Acast. See acast.com/privacy for more information.
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About Inside GRAPPA
Welcome to Inside GRAPPA, a podcast and brought to you by the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA). Our mission is to enhance understanding and treatment of psoriasis and psoriatic arthritis through the sharing of research, knowledge, and collaborative efforts.We bring together leading rheumatologists, dermatologists, scientists, patient representatives, and industry partners, uniting our passions to make a difference for those living with these conditions.Join our host Fabian Proft as we navigate the challenges, share the latest research, and explore the triumphs in the world of psoriasis and psoriatic arthritis. Together, we can make a difference. Hosted on Acast. See acast.com/privacy f
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