Her Path to Success

Tiny Worms, Big Questions: Dr. Anne Hart on Decoding the Brain

August 24, 2026·15 min
Episode Description from the Publisher

How can a microscopic worm help us understand some of the most complex diseases of the human brain?In this episode of Her Path to Success, I speak with Dr. Anne Hart, Professor and Chair of Neuroscience at Brown University, whose research uses the tiny nematode C. elegans to uncover fundamental mechanisms of the nervous system.Dr. Hart shares her journey into neuroscience and how her research has helped illuminate questions surrounding neurodegenerative diseases such as ALS, as well as sleep, fatigue, stress, and sensory signaling. We also discuss the power of simple model organisms to answer surprisingly complex questions, the unexpected turns that shape a scientific career, and her advice for young people hoping to enter neuroscience and research.This conversation is a reminder that some of science's biggest discoveries can begin with the smallest subjects.

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