From First Principles

Nobel Prize 2026: The Science Gets Stranger

October 16, 2026·1h 59m
Episode Description from the Publisher

Can light restore aspects of sight? Can recalling a cold experience change an animal's metabolism? And what can ghost particles and mirror-image molecules tell us about the universe?Lester Nare and Krishna Choudhary follow up on our 2026 Nobel Prize episodes with research building on optogenetics, IceCube and molecular handedness. We unpack an early human vision-restoration trial, cold-memory experiments in mice, cosmic neutrino flavors, and a tiny electrical sensor for distinguishing left- and right-handed amino acids.Plus: how the Nobels work, our follow-up on the Nobel chemistry illustration, a brief look at neutrino Earth tomography, and why fundamental research matters. Which discovery would you like us to explore next?CHAPTERS00:00 Cold open: memory, neutrinos and mirror molecules00:28 Hello Internet and how the Nobels work04:32 Optogenetics recap10:23 Restoring aspects of vision25:43 Controlling movement in worms29:31 Cold memories and metabolism41:07 Memory, trauma and ethical questions45:44 FFP housekeeping48:17 IceCube recap56:23 Measuring cosmic neutrino flavors1:10:30 A brief look at neutrino Earth tomography1:12:20 Why fundamental physics matters1:26:58 Chemistry and molecular handedness1:29:08 Correcting the Nobel illustration1:39:30 Measuring chirality in tiny samples1:46:42 Testing the sensor on meteorite and desert samples1:51:22 Why these questions matter1:57:20 Closing thoughts and signoffRESEARCH & FURTHER READINGOptogenetic therapy for visual function (NEJM, 2026):https://doi.org/10.1056/NEJMoa2602215Cold memories and thermoregulation (Nature, 2025):https://doi.org/10.1038/s41586-025-08902-6Three-flavor composition of cosmic neutrinos (PRL, 2026):https://doi.org/10.1103/vntd-m133Chiral discrimination in meteorite and desert soil extracts (Nature Communications, 2026):https://doi.org/10.1038/s41467-026-77947-6Further reading, briefly mentioned: neutrino Earth tomography (preprint):https://arxiv.org/abs/2607.02644EDITORIAL NOTESThe vision trial was small and exploratory. The cold-memory findings discussed are from mice.On-screen clarifications:16:53 Both eyes were profoundly visually impaired; the worse-seeing eye was treated.19:57 The untreated eye was patched during testing, not a normal-vision control.54:41 Neutrino event rates depend on energy and selection, not just detector volume.1:05:47 Flavor identification efficiency is distinct from interaction probability; both depend on energy.1:13:35 Other astronomy-related Nobels include 2017 (LIGO) and 2019 (cosmology/exoplanets).1:18:00 The LHC at CERN enabled the Higgs discovery; CERN itself was founded in 1954.1:44:25 Both enantiomers produce current signals; waveform features distinguish them.1:46:42 Murchison is a meteorite. Diego de Almagro and North of Antofagasta are soil sites.1:47:40 The sensor study reports mixed agreement and limitations, not uniformly negative results.1:49:00 Phobos is a Martian moon; a captured-asteroid origin is a hypothesis.WATCH & LISTENFull video: https://youtu.be/C9K6onZxyN4Episode notes: https://ffppod.com/episodes/ep64Follow @FFPPod on Instagram, TikTok, X and Facebook.Breaking down science news so it makes sense to curious people everywhere.

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