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- Mar 30, 20261h 35m
FF91 Liberate-D
The FiltrateJoel Topf kidneyboy.bsky.socialPedro Teixeira @nephcrit.bsky.socialNayan Arora @captainchloride.bsky.socialAnna Gaddy @annagaddy.bsky.social Swapnil Hiremath @hswapnil.medsky.social and on LinkedInSpecial GuestsIan McCoy, MD @NephroNinja study author and UCSFChi-yuan Hsu Senior author and Chief of the Division of Nephrology at UCSFSamuel Silver Associate Professor at Queens University in CanadaEditingVipin Verghese and Joel TopfShow Notes NephJC Discusion: Dialyze Less, Recover More? AKI’s Chance to Get LIBERATE-DManuscript: A Conservative Dialysis Strategy and Kidney Function Recovery in Dialysis-Requiring Acute Kidney InjuryThe Liberation From Acute Dialysis (LIBERATE-D) Randomized Clinical Trial JAMA | PubMedBen’s pilot study: RAD-AKI Pilot study: Recovery After Dialysis-Requiring Acute Kidney Injury (RAD-AKI) (ClinicalTrials.gov)STARRT-AKI NephJC Editorial in JAMA: A-E-I-O-U and Sometimes Why—Dialysis in Acute Kidney Injury (JAMA)What Is Dialytrauma? (Nephrology Times)How Fragile Are the Results of a Trial? The Fragility Index (PubMedCentral)Shiffl Trial: Daily Hemodialysis and the Outcome of Acute Renal Failure (NEJM)AKIKI: Initiation Strategies for Renal-Replacement Therapy in the Intensive Care Unit (NEJM)AKIKI2: How Late it was, How Late! (NephJC)Sam Silver’s study: Promoting Kidney Recovery After Acute Kidney Injury Receiving Dialysis (Recover-AKI) (<a href="https:
- Mar 21, 20261h 25m
FF90 NephMadness 2026: Animal House
The FiltrateJoel Topf (kidneyboy.bsky.social)AC (@medpeedskidneys.bsky.social)NephMadnessAnna Gaddy (@AnnaGaddy) Vipin Verghese (@vipvargh.bsky.social) Natalie Freidin Program director at Medical University of South CarolinaSpecial GuestsAnna Vinnikova (@kidneywars.bsky.social) Long time game maker for NephMadness and Associate Professor at Virginia Commonwealth UniversityAutumn Harris Associate Professor of Veterinary Medicine at NC StateSarah Street MD PhD Assistant Professor of Medicine at Virginia Commonwealth UniversityEditingJoel TopfShow Notes Animal House scouting reportAutumn Harris on Team CatCheese!
- Jan 31, 20261h 51m
FF 89 Top Stories of 2025
I know 2026 feels like it ihas been here for months, but only a few weeks ago we were celebrating the nephrology accomplishments of 2025. The New Filtrate came together to review the year.The FiltrateJoel Topf @kidneyboy.bsky.social (COI)Swapnil Hiremath @hswapnil.medsky.social and on LinkedIn Editor in Chief of Kidney International Case ReportsAnna Gaddy (@AnnaGaddy) Winner of NephJC Rookie of the Year 2020Nayan Arora (@CaptainChloride.bsky.social)AC (@medpeedskidneys.bsky.social)Vipin Verghese (@vipvargh.bsky.social) co-winner of NephJC Engaged Scientist of the Year in 2021Brian Rifkin (@brianrifkin.bsky.social) Co-Editor in Chief NephJC. Winner of NephJC Rookie of the Year 2021Cristina Popa (@NephroSeeker) Co-Editor in Chief NephJC. Wwinner of NephJC Rookie of the Year 2022 and MVP 2023Editing and Show Notes byAnna Gaddy and Joel TopfThe Kidney Connection written and performed by Tim YauShow NotesTop Stories in Nephrology 2025 (NephJC)First Top sories in Nephrology 2010! (Renal Fellow Network)Links to all of the Top Stories in Nephrology, hosted on NephJC since 2017 (NephJC)1. IgA NephropathyVISIONARY: Sibeprenlimab in IgA Nephropathy — Interim Analysis of a Phase 3 Trial (NEJM)ORIGIN 3: A Phase 3 Trial of Atacicept in Patients with IgA Nephropathy (NEJM)APPLAUSE-IgA Alternative Complement Pathway Inhibition with Iptacopan in IgA Nephropathy (NEJM)Aliza M. Thompson, MD, MS (ASN) 2. Lupus NephritisREGENCY: Efficacy and Safety of Obinutuzumab in Active Lupus Nephritis (NEJM)<p class="" data-rte-preserve-empty="true" style="white-space:pre-wra
- Dec 28, 20251h 15m
FF 86 Atacicept for IgAN. Third attempt
The FiltrateJoel Topf @kidneyboy.bsky.social (COI)Sophia Ambruso @sophia-kidney.bsky.socialSwapnil Hiremath @hswapnil.medsky.social and on LinkedInSpecial Guests Jonathan Barratt Professor of Renal Medicine, University of Leicester Google Scholar (COI: all the companies)Editing and Show Notes byNayan Arora @captainchloride.bsky.socialThe Kidney Connection written and performed by Tim YauShow NotesProteinuria Reduction as a Surrogate End Point in Trials of IgA Nephropathy (Aliza Thompson, 2019 PubMed)The number, quality, and coverage of randomized controlled trials in nephrology (PubMed 2004)A Randomized, Controlled Trial of Rituximab in IgA Nephropathy with Proteinuria and Renal Dysfunction (PubMed 2017)BLISS Belimumab in lupus nephritis (NephJC | PubMed)The Phase 2 trial of atacicept A phase 2b, randomized, double-blind, placebo-controlled, clinical trial of atacicept for treatment of IgA nephropathy (PubMed)The phase 3 trial of atacicept, the subject of this podcast A Phase 3 Trial of Atacicept in Patients with IgA Nephropathy (PubMed | NephJC)The use of Gd-IgA1 in the Testing Trial Role of Systemic Glucocorticoids in Reducing IgA and Galactose-Deficient IgA1 Levels in IgA Nephropathy (PubMed)If you can’t get enough Jon Barratt, take a look at his grand rounds at The University of Ottawa. Updates to the KDIGO Guidelines for the treatm
- Dec 27, 20251h 24m
FF 88 BICARICU-2, Bicarbonate in the ICU, still not helpful?
The FiltrateJoel Topf @kidneyboy.bsky.social (COI)Pedro Teixeira @nephcrit.bsky.socialAna Gaddy @AnnaGaddyNayan Arora @captainchloride.bsky.socialSpecial Guests David Goldfarb Professor of Medicene, NYU (COI)Editing byPedro TeixeiraThe Kidney Connection written and performed by Tim YauShow NotesBICARBICU 2018 (Lancet) BICARBICU-2 2025 (JAMA)SOFA score (Wikipedia)Sodium bicarbonate administration for metabolic acidosis in the intensive care unit: a target trial emulation (PubMed)Effect of sodium bicarbonate on intracellular pH under different buffering conditions (PubMed)Evaluating the clinical and cost-effectiveness of Sodium Bicarbonate administration for critically ill patients with Acute Kidney Injury (MOSAICC) (ICNARC Site)SODium BICarbonate for Metabolic Acidosis in the ICU (SODa-BIC) (ClinicalTrials.gov)Surviving Sepsis Campaign Guidelines 2021 (Website)Tubular SecretionsNayan: Louise Penny, The Black Wolf (Amazon)Anna: Broom Gate: A Curling Scandle (CBC) Pedro: One Battle After Another! (Wikipedia)David: Patti Smith (Wikipedia) Bonus pick: Kids Rarely Read Whole Books Anymore. Even in English Class. (<a target="_
- Dec 14, 20251h 20m
FF 87 Can Fish Oil Knock the Crap out of Dialysis Associated CV Disease?
The FiltrateJoel Topf @kidneyboy.bsky.social (COI)Swapnil Hiremath @hswapnil.medsky.social and on LinkedInPedro Teixeira @nephcrit.bsky.socialSpecial Guests Charmaine E Lok, MD Professor of Medicine at the Faculty of Medicine, University of TorontoEditing and Show Notes byJoel TopfThe Kidney Connection written and performed by Tim YauShow NotesFish-Oil Supplementation and Cardiovascular Events in Patients Receiving Hemodialysis NEJM | NephJCWhat works in hemodialysis?Iron: PIVOTAL Trial (NEJM)Hemodiafiltration: CONVINCE (NEJM)That’s the whole listEarlier work on vascular access, The FISH Trial: Effect of fish oil supplementation on graft patency and cardiovascular events among patients with new synthetic arteriovenous hemodialysis grafts: a randomized controlled trial JAMAEskimo myth: "Fishing" for the origins of the "Eskimos and heart disease" story: facts or wishful thinking? (PubMed)Dialysis patients have low levels of fish oil in their body (PubMedCentral)Positive trial in non-dialysis patients: REDUCE-ITNegative trial of fish oil in non-dialysis patients: STRENGTHACC does not recommend FISH Oil for primary or secondary prevention of CV events (ACC)Poisson distribution (Wikipedia)Ocean Nutrition Canada (Wikipedia)Ocean Nutrition was bought by DSM (Press Release)DSM merged with Firmenich (<a target="_bla
- Nov 28, 20251h 15m
FF 86 Atacicept for IgAN with Jon Barratt
The FiltrateJoel Topf @kidneyboy.bsky.social (COI)Sophia Ambruso @sophia-kidney.bsky.socialSwapnil Hiremath @hswapnil.medsky.social and on LinkedInSpecial Guests Jonathan Barratt Professor of Renal Medicine, University of Leicester Google Scholar (COI: all the companies)Editing and Show Notes byNayan Arora @captainchloride.bsky.socialThe Kidney Connection written and performed by Tim YauShow NotesProteinuria Reduction as a Surrogate End Point in Trials of IgA Nephropathy (Aliza Thompson, 2019 PubMed)The number, quality, and coverage of randomized controlled trials in nephrology (PubMed 2004)Updated here (PubMed | NephJC discussion)A Randomized, Controlled Trial of Rituximab in IgA Nephropathy with Proteinuria and Renal Dysfunction (PubMed 2017)BLISS Belimumab in lupus nephritis (NephJC | PubMed) The Phase 2 trial of atacicept A phase 2b, randomized, double-blind, placebo-controlled, clinical trial of atacicept for treatment of IgA nephropathy (PubMed)The phase 3 trial of atacicept, the subject of this podcast A Phase 3 Trial of Atacicept in Patients with IgA Nephropathy (PubMed | NephJC)Christos’ Bluesky post:https://bsky.app/profile/christosargyrop.bsky.social/post/3m5bsujwg3s2q The use of Gd-IgA1 in the Testing Trial Role of Systemic Glucocorticoids in Reducing IgA and Galactose-Deficient IgA1 Levels in IgA Nephropathy (PubMed)If you can’t get enough Jon Barratt, take a look at his grand rounds at The University of Ottawa. Updates to the KDIGO Guidelines for the treatment of IgA nephropathy, with Prof Jonathan Barratt (YouTube)Tubular SecretionSwapnil Hiremath Pluribus on Apple TV (<a target="_b
- Nov 17, 202549 min
FF 85 Live at Kidney Week
The FiltrateJoel Topf @kidneyboy.bsky.socialSophia Ambruso @sophia-kidney.bsky.socialNayan Arora @captainchloride.bsky.socialSpecial Guests Brian Rifkin @brianrifkin.bsky.socialAnna Gaddy @AnnaGaddyEditing and Show Notes byJoel TopfThe Kidney Connection written and performed by Tim YauShow NotesBrian Rifkin and Cristina Popa ascend to co-editors in chief of NephJC.Paresh Jadav receives the first NephJC Champion award. Dr. Jadav hosted the NephJC night and saved NephJC thousands of dollars. It makes a huge difference in our fund raising. Thank you.Also a big thank-you to Jade Teakell for buying the cowboy hats!The first pick of the draft, by Sophia is Fish oil for dialysis: Fish-Oil Supplementation and Cardiovascular Events in Patients Receiving Hemodialysis (NEJM)The second pick, by Brian is FINE-ONE (Bayer Press release)Rajiv Agarwal’s mediation analysis to show how much of finerenone’s beneficial renal effects are captured by the reduction proteinuria: Impact of Finerenone-Induced Albuminuria Reduction on Chronic Kidney Disease Outcomes in Type 2 Diabetes : A Mediation Analysis (PubMed)Anna has the third pick and it goes to Katherine Tuttle and the REM0DEL Trial: REMODELing mechanistic trials for kidney disease: a multimodal, tissue-centered approach to understand the renal mechanism of action of semaglutide (Science Direct)Nayan goes off-board and picks a poster by a med student (backed by Testani)Mechanism and Effects of Manipulating Chloride Homeostasis in Stable Heart Failure (ClinicalTrials.gov)For the final pick in the draft Joel went with a little Lilly on Lilly violence: Tirzepatide vs. Dulaglutide Is Associated with Reduced Major Kidney Events in Patients with Type 2 Diabetes, CVD, and Very High-Risk Kidney Diseases (JASN)Bring out your dead…What’s left on the draft board.Liberate-D A Conservative Dialysis Strategy and Kidney Function Recovery in Dialysis-Requiring Acute Kidney Injury: The Liberation From Acute Dialysis (LIBERATE-D) Randomized Clinical Tr
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About Freely Filtered, a NephJC Podcast
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