Frankly Speaking About Family Medicine

Leucovorin for Autism Spectrum Disorder: Is There Any Evidence Behind the Hype? - Frankly Speaking Ep 501

September 7, 2026·11 min
Episode Description from the Publisher

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-501 Overview: Leucovorin has gained growing attention as a treatment for autism spectrum disorder (ASD), despite limited supporting evidence. In this episode, we discuss the rationale behind its use, review the current literature, and examine the American Academy of Pediatrics’ guidance on this treatment for ASD, giving you confidence to counsel families and engage in meaningful shared decision-making. Episode resource links: Discuss the rationale for using leucovorin in treatment of autism spectrum disorder (ASD) Review current evidence and practice guidelines regarding leucovorin and ASD Examine data and recent national trends in prescription rates of leucovorin for ASD Guest: Anne Powell, MD   Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.

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