Beyond Small Molecules—Allometric Scaling for Biologics and Engineered mAbs (Ep. 58)

Today’s episode is about allometric scaling with therapeutic antibodies. I discuss differences from small molecules, how to handle antibodies with engineered Fc regions (e.g. YTE or LS), and using allometry to extrapolate from adults to pediatrics for these antibodies. Links discussed in the show:Haray and Tachibana’s article on allometric exponents for monoclonal antibodies Exponents for standard antibodies: CL = 0.8, Q = 0.75, Vc = 1/.0, Vp = 0.95Exponents for modified antibodies: CL = 0.55, Q = 6, Vc = 0.95, Vp = 0.95You can connect with me on LinkedIn and send me a message Send me a message Sign up for my newsletter Copyright Teuscher Solutions LLCAll Rights Reserved