Bryan Johnson Podcast

Ketamine & Cocaine: Ranking Drugs for Longevity (Part 1)

September 4, 2025·50 min
Episode Description from the Publisher

Can doing lines help you live longer? That depends on what you’re taking. In this three-part series, I’m ranking drugs based on their ties to longevity, starting with ketamine and cocaine. I tested ketamine on myself to study its impacts on the brain — here’s what we found.   Study Links: Ketamine’s Effects on Epigenetic Age  Extending Ketamine’s Therapeutic Window Ibogaine Therapy for PTSD  Hosts: Bryan Johnson: Blueprint Founder Kate Tolo: Blueprint Co-Founder Dr. Mike Mallin: Lead Physician for Bryan Johnson Connect:  X: https://x.com/bryan_johnson YouTube: https://www.youtube.com/@BryanJohnson Instagram:  https://www.instagram.com/bryanjohnson   TikTok:  https://www.tiktok.com/@_bryan_johnson_ Chapters:  00:00 - Introduction  03:14 - Social Norms Around Drugs  08:59 - Psychedelics as Therapy: Overview  10:20 - Cocaine  17:15 - Fentanyl Dangers  23:27 - Ketamine: Brain Impacts + Longevity  41:29 - Measuring The Impacts of Psychedelics   47:51 - Longevity Rankings: Cocaine + Ketamine

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