Karpathy’s autoresearch could make scientists of us all

Welcome to Exponential View, the show where I explore how exponential technologies such as AI are reshaping our future. I’ve been studying AI and exponential technologies at the frontier for over ten years. Each week, I share some of my analysis or speak with an expert guest to make light of a particular topic. To keep up with the Exponential transition, subscribe to this channel or to my newsletter: https://www.exponentialview.co/ ---- Published in early March 2026, Andrej Karpathy's autoresearch AI tool makes autonomous scientific experimentation cheap and easy — but it was designed to solve machine learning problems. I wanted to see if I could apply its loop architecture to my own work: refining my worldview, testing arguments, solving business problems. In this video, I share how I adapted Karpathy’s autoresearch loops for problems that aren't easy to quantify, how to avoid the local minima trap, and the broader impact of these kinds of methods. I covered: (02:11) The Karpathy Loop: what is it and how does it work (07:54) Extending the loop into business and thinking (09:46) The local minima trap (12:20) The escape harness: getting beyond “good enough” (16:05) What I’ve learned after 30 days (18:47) The loop economy: from doing to judging ---- Where to find me: Exponential View newsletter: https://www.exponentialview.co/ Website: https://www.azeemazhar.com/ LinkedIn: https://www.linkedin.com/in/azeem/ Twitter/X: https://x.com/azeem Production by EPIIPLUS1. Production and research: Baba Films, Chantal Smith, Marija Gavrilov. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.