Unmet needs in paediatric diabetes – the potential role of inhaled insulin

Join host Dr. David Ahn and guest Dr. Michael Haller (Professor and Chief of Pediatric Endocrinology at the University of Florida and Chair of TrialNet) as they take a comprehensive review of the evidence base and remaining gaps for inhaled insulin use in pediatric and adolescent populationsIn this final episode, we dive into:Key Challenges in Pediatrics: Unmet needs in pediatric insulin therapy, including injection fatigue and tech-retention issues for active youth.The INHALE-1 Study: A deep dive into the randomized controlled trial data of 230 youth, highlighting efficacy, per-protocol non-inferiority, less weight gain, and superior treatment satisfaction among kids and parents.Safety Profile: Analyzing forced expiratory volume (FEV1) data showing an excellent safety signal with no differences in pulmonary function or severe hypoglycemic events.Practical Toolkit Use Cases: How the unique pharmacokinetic profile of inhaled insulin provides unmatched benefits for covering adrenaline-rush highs and avoiding hypoglycemia tail effects during sports and exercise.Dosing Guidelines: Overcoming the practical "paradigm shift" of converting injected units to inhaled units and managing dosing effectively.Future Horizons: Anticipating the "INHALE FIRST" study investigating early onboarding for newly diagnosed patients and introducing a new two-unit inhaled insulin cartridge.About ATTD Diabetes Talks:A podcast series dedicated to providing healthcare professionals with the latest knowledge and best practices in diabetes management, supported by MannKind Corporation.Find more resources on the ATTD Education Portal: https://unlok-education.com/attd/Subscribe to the podcast for more updates on advancing diabetes care.#DiabetesManagement #PediatricEndocrinology #InhaledInsulin #ATTD #DiabetesCare #MedicalPodcast #Type1DiabetesChapters:00:00 Intro and Unique Challenges in Pediatric Diabetes Management02:38 The INHALE-1 Study: Efficacy, Satisfaction, and Weight Findings06:27 Safety Signals, Pulmonary Function, and Adherence Challenges10:18 Practical Toolkit Use Cases: Managing Sports and Exercise12:48 Dosing Conversions and Practical Patient Selection Guidelines15:02 Off-Label Integration with Automated Insulin Delivery (AID) Systems20:14 Caregiver & School Nurse Roles and Managing Safety Concerns22:00 Research Gaps, The INHALE FIRST Trial, and Wrap Up