Modeling Eosinophilic Esophagitis: Insights from Mouse Models into Mechanisms and Therapies

In this episode, coauthors Jazmyne L. Jackson, Abigail J. Staub, Annie D. Fuller, and Kelly A. Whelan join us to discuss their recently published review, "Mouse models of eosinophilic esophagitis: molecular and translational insights." Eosinophilic esophagitis (EoE) is a chronic allergic inflammatory disease of the esophagus with growing prevalence and clinical impact, yet many of its underlying mechanisms remain poorly understood. The authors explore how murine models have advanced our knowledge of EoE pathogenesis, highlighting key molecular and translational findings uncovered through in vivo research. This episode delves into the strengths and limitations of existing models, current challenges, and future opportunities for leveraging mouse models to guide diagnosis, monitoring, and therapy development in EoE.   Mouse models of eosinophilic esophagitis: molecular and translational insights Jazmyne L. Jackson, Abigail J. Staub, Annie D. Fuller, John M. Crespo, Travis H. Bordner, Courtney Worrell, No’ad Shanas, Danielle Waheed, Tatiana A. Karakasheva, Melanie Ruffner, Amanda B. Muir, and Kelly A. Whelan American Journal of Physiology-Gastrointestinal and Liver Physiology 2025 329:1, G215-G231