Adventures Through The Mind

MICRO:15 — Ibogaine: the one drug that stops opioid addiction in a single session, and can also kill you ~ James W. Jesso

June 19, 2026·21 min
Episode Description from the Publisher

Ibogaine is regularly categorized as a psychedelic — but that label may be misleading in ways that matter. In this micro, James offers a crash course in what ibogaine actually is: where it comes from, how its unusual pharmacology works, what it does to the mind, and why it holds a position in addiction medicine that no other drug on earth can claim. The risk profile is part of the picture too. This is a clip from 'Psychedelics in Research & Practice | James W. Jesso', Adventures Through The Mind Podcast, episode 200 FULL EPISODE Listen on Apple Podcasts Listen on Spotify Watch on YouTube Read the show notes MORE IBOGAINE EPISODES Treating Traumatic Brain Injury with Ibogaine | Dr. Nolan Williams ~ ATTMind 188 Ibogaine Medical Subculture | Jonathan Dickinson ~ ATTMind 003 SUPPORT THE PODCAST 🥰 Support ATTMind and join the community on Patreon Other options Toss me a tip on PayPal: https://www.paypal.com/biz/fund?id=383635S3BKJVS Buy some merchandise: https://www.jameswjesso.com/shop/ More Options: https://www.jameswjesso.com/support Connect with Me Bluesky: https://bsky.app/profile/jameswjesso.bsky.social LinkedIn: https://www.linkedin.com/in/james-w-jesso-64361812b/ Instagram: https://www.instagram.com/attmindpodcast/ Newsletter: https://www.jameswjesso.com/newsletter Substack: https://substack.com/@jameswjesso Telegram Channel: https://t.me/jameswjesso EPISODE BREAKDOWN AND TIMESTAMPS (00:00) — What is ibogaine? (00:43) — An oneirogen, not a psychedelic (01:33) — Closed-eye visuals and the life review (02:02) — Pharmacological complexity: the "14th century key" metaphor (04:39) — Duration and physical challenges of the experience (06:34) — Cardiac risk: the only psychedelic that can directly cause death (09:01) — Encountering ancestors and the Bwiti tradition (09:51) — A brief history: from West Africa to underground use (10:58) — Stopping opioid addiction in a single session (12:21) — The current treatment landscape (14:44) — Reversing traumatic brain injury: the Stanford research (18:47) — Brain de-aging and multiple sclerosis potential (19:53) — Outro

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